Lynch Syndrome dramatically increases the risk of colon cancer. The lifetime risk estimates are 54-74% for men and 30-52% for women for MLH1 and MLH2 gene mutation carriers and 44-69% for men and 20-30% for women for MSH6 carriers.
Lynch Syndrome also increases the risk of other cancers. The most common is endometrial with a 42% to 71% lifetime risk. This includes endometrial adenocarcinoma, clear cell carcinoma, uterine papillary serous carcinoma and malignant mixed Mullerian tumors. Lynch Syndrome is also associated with cancers of the stomach (6-9%), small intestine (3-4%), hepatobiliary (1%), brain (2-3%), ovary (6-12%), ureter and renal pelvis (3-8%). Can also add pancreas (1-4%) and sebaceous gland neoplasms (1-9%).