Screening Criteria

Amsterdam Criteria

An international collaborative group met in Amsterdam in 1991 to establish guidelines for identifying Lynch Syndrome families.

  1. Three affected relatives with colorectal cancer, one of them a first-degree relative of the other two.
  2. AND colorectal cancer in at least 2 generations.
  3. One family member diagnosed with colorectal cancer before age 50 years.
  4. AND Familial Adenomatous Polyposis (FAP) should be excluded.

Amsterdam Criteria II

Because genetically abnormal families were identified that did not meet the above guidelines, a revised criteria were published in 1999.

  1. There should be at least three relatives with a Lynch Syndrome –associated cancer (colorectal, endometrial, small bowel, ureter or renal pelvis).
  2. One should be a first-degree relative of the other two.
  3. At least two successive generations should be affected.
  4. At least one should be diagnosed before age 50 years.
  5. Familial adenomatous polyposis should be excluded in the colorectal cancer cases.

Revised Bethesda Guidelines

A third set of criteria can also be used to identify Lynch Syndrome families.

  1. Colorectal cancer diagnosed in an individual younger then 50 years.
  2. Presence of synchronous metachronous colorectal, or other Lynch Syndrome–associated tumors in an individual regardless of age.
  3. Colorectal cancer with MSI-high pathologic associated features diagnosed in an individual younger than 60 years.
  4. Colorectal cancer or Lynch Syndrome-associated tumor diagnosed in at least one first –degree relative younger than 50 years.
  5. Colorectal cancer or Lynch Syndrome-associated tumor diagnosed at any age in two first-degree or second-degree relatives.