Fertility Issues

One of the biggest concerns people have is passing a hereditary disease, like Lynch syndrome to their children. Because Lynch syndrome is autosomal dominant, there is a 50% chance of passing this on to offspring. To avoid this risk, Preimplantation Genetic Testing for Monogenic Diseases (PGT-M) can be utilized. Once a polymorphism or Lynch causing gene is identified, reproductive specialists can identify affected genes in the embryos created during an In-vitro fertilization cycle. By having this information, embryos not affected by the condition can be selected and be transferred to patients yielding a normal pregnancy and an unaffected baby, therefore cutting the Lynch hereditary transmission. Albeit some fertility treatments like this can sometimes be expensive or present limitations in access to care, PGT-M it is one of the best options to date in order to prevent the transmission of Lynch syndrome. These technologies shed some light and promise for the future of reproductive choices in patients with Lynch and should be broadly discussed at the onset of a diagnosis for Lynch syndrome.

In Vitro Fertilization